The foot and bike path of the Ticino starts at the bridge that unites Castelletto with Sesto Calende. The first stretch shares limited car traffic up to the crossroads with state route 336. From this point, signs of humans are limited to the works that block or deviate the currents to supply the electricity plants, canals and waterways and the route is safe until its end near the bridge of Tornavento. The bike path is well-marked and there is no risk of getting lost among the numerous passages from one towpath to another or the many junctions.
To return to the starting point, you can go to the train station of Oleggio. Follow a brief stretch of state route 527 carefully beyond the iron bridge to the first curve, then turn right onto the old Via Vecchia Ticino, which will bring you to the train station after about 6 km.
It is best to inquire in advance about schedules and the possibility to load bicycles on board.